Leukeran (Chlorambucil) – What It Is, How It Works, and What to Expect

If your doctor mentioned Leukeran, you probably wonder what the pill does and whether it’s right for you. Leukeran is the brand name for chlorambucil, an oral chemotherapy drug used mainly for certain blood cancers like chronic lymphocytic leukemia (CLL) and some types of lymphoma. It’s taken by mouth, which makes it easier than IV chemo for many patients.

Leukeran works by damaging the DNA inside rapidly dividing cells. Cancer cells rely on fast DNA replication, so the drug slows their growth and eventually triggers cell death. Unfortunately, it can also affect some healthy cells that divide quickly, such as those in your bone marrow or lining of the gut. That’s why side effects show up, especially early in treatment.

Typical Dosage and How to Take It

Doctors usually start with a low dose, often 0.5 mg per kilogram of body weight once a day for a few weeks, then adjust based on blood tests. Some patients stay on the same dose for months; others may have short courses followed by breaks. Always swallow the tablet whole with a full glass of water. Don’t crush or chew it, because that can release too much drug at once.

Timing matters. Take Leukeran at the same time each day, preferably after a meal to reduce stomach upset. If you miss a dose, take it as soon as you remember—unless it’s almost time for the next dose. In that case, skip the missed one and continue with your regular schedule. Never double up.

Common Side Effects and When to Call the Doctor

Because Leukeran hits fast‑dividing cells, you may notice low blood counts. That means you could feel more tired, get infections easier, or bruise and bleed more. Your doctor will check your blood every couple of weeks, especially at the start. If you develop a fever, sore throat, or unusual bleeding, call the clinic right away.

Other frequent complaints are nausea, mild stomach cramps, and loss of appetite. Eating small meals, staying hydrated, and avoiding spicy or greasy foods can help. Some people get a rash or itchy skin—usually not serious, but tell your doctor if it spreads.

Long‑term use can raise the risk of a second cancer, although that’s rare. Regular check‑ups and monitoring keep this risk low. If you’re pregnant or planning a pregnancy, discuss alternatives, because Leukeran can harm a developing baby.

Safety Tips and Practical Advice

Keep a medication list handy and share it with any pharmacist or new doctor. Store Leukeran at room temperature, away from moisture and direct sunlight. If you have children at home, keep the bottle locked away—accidental ingestion can be dangerous.

Don’t start any new over‑the‑counter meds or supplements without checking with your oncologist. Some vitamins, especially high‑dose antioxidants, might interfere with how Leukeran works. Also, limit alcohol, as it can worsen liver strain.

Track how you feel each day. A simple notebook or a phone note can capture side effects, their severity, and any patterns. This record helps your doctor fine‑tune the dose or suggest supportive meds like anti‑nausea tablets or growth‑factor injections.

Finally, remember that every cancer journey is personal. Some patients feel better quickly, while others need dose adjustments. Stay in close contact with your care team, ask questions, and lean on support groups. With the right monitoring, many people manage Leukeran’s side effects and keep their disease under control.